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Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
ProstaglandinF2α methyl ester (PGF2α methyl ester; Dinoprost methyl) is a PGF2α analog with more lipid solubility. ProstaglandinF2α methyl ester exhibits efficacy in maintaining the ocular hypotensive .
ProstaglandinF2α ethanolamide (Prostamide F2α) is an ethanolamide-like G protein-coupled receptor. ProstaglandinF2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord .
ProstaglandinF2α dimethyl amine is a ProstaglandinF2α (HY-12956) derivative. ProstaglandinF2α dimethyl amine is an antagonist for Prostaglandin F receptor (FP) . ProstaglandinF2α dimethyl amine blocks the cardiovascular responses induced by orexin and Arachidonic acid (HY-109590) .
ProstaglandinF2α ethyl amide is an analog of ProstaglandinF2α (HY-12956). ProstaglandinF2α ethyl amide is supposed to be potent lowering intraocular pressure (IOP) for its N-ethyl amide group, like Bimatoprost (HY-B0191) .
ProstaglandinF2α dimethyl amide is an antagonist for ProstaglandinF2α (HY-12956), which blocks 50% contraction on gerbilMeriones unguiculatus colon induced by PGF2α at 3.2 μg/mL .
ProstaglandinF2α alcohol methyl ether is an alcohol methyl ether G protein-coupled receptor. ProstaglandinF2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord .
ProstaglandinF2α serinol amide is a serinolamide G protein-coupled receptor that increases calcium levels in human non-small cell lung cancer cells. ProstaglandinF2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord .
ProstaglandinF2α alcohol (PGF2α alcohol) is an analog of PGF2α. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist .
ProstaglandinF2α 1,11-lactone is a prostaglandin.
ProstaglandinF2α 1,11-lactone is absorbed by the eye. ProstaglandinF2α 1,
11-Lactone has metabolic stability on the corneal surface and conjunctiva.
ProstaglandinF2α 1,11-lactone can be used in the treatment of glaucoma
.
Dinoprost tromethamine salt (ProstaglandinF2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour .
PGF2α 1,15-lactone (ProstaglandinF2α 1,15-lactone) is a lipid-soluble internal ester of PGF2α. PGF2α 1,15-lactone decreases menstrual cycle lengths in non-pregnant rhesus monkeys. PGF2α 1,15-lactone terminates early pregnancy in the monkey .
Dinoprost- 13C5 is 13C labeled Dinoprost (HY-12956). Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
16-Phenoxy tetranor ProstaglandinF2α methyl ester is a metabolically stable form of ProstaglandinF2α that can binds to FP receptor. 16-Phenoxy tetranor ProstaglandinF2α methyl ester serves as prodrug that can be hydrolyzed to generate bioactive free acid .
Carboprost (15(S)-15-Methyl ProstaglandinF2α) is a metabolically stable synthetic analog of prostaglandinF2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .
Ent-8-Iso-15(S)-prostaglandinF2α is an isomer of 8-Isoprostaglandin F2α, with a better inhibiting activity in the whole blood platelet aggregation inhibition assay .
17-Phenyl trinor ProstaglandinF2α dimethyl amide (Bimatoprost dimethyl amide), a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivative, is a smooth muscle relaxant. 17-Phenyl trinor ProstaglandinF2α dimethyl amide has the potential for glaucoma research .
8-iso-15-keto ProstaglandinF2α (8-iso-15-keto PGF2α) is a partial agonist for Thromboxane receptor (TP), which exhibits a vasoconstrictor efficacy with a pD2 of 5.8. 8-iso-15-keto ProstaglandinF2α mediates a weak relaxation of rats aorta rings at high concentration .
ent-8-iso ProstaglandinF2α (ent-15-F2t-IsoP) is a potent vasoconstrictor of porcine retina and cerebral microvessels with EC50 values of 30.6 and 53.5 nM, respectively .
17-Trifluoromethylphenyl trinor prostaglandinF2α ethyl amide (compound 17-CF3PTPG2α EA) is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α .
8-iso ProstaglandinF2α-d9 is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
15-keto-ProstaglandinF2α (15-keto-PGF2α) is a metabolite of ProstaglandinF2α. ProstaglandinF2α. ProstaglandinF2α is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist and plays a key role in the onset and progression of labour .
AS604872 is an orally active, potent and selective prostaglandinF2α receptor (FP) antagonist with a Ki of 35 nM in humans, 158 nM in rats and 323 nM in mice. AS604872 inhibits contractions and delays labour .
(±)5-iPF2α-VI (5-iso ProstaglandinF2α-VI) is the racemate of 5-iPF2α-VI. 5-iPF2α-VI is a regioisomeric isoprostane formed from arachidonic acid (AA) and is a biomarker of oxidative stress .
Unoprostone, a prostaglandinF2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension .
AL 8810 methyl ester is a prostaglandinF(2α) analog and a prostaglandinF(2α) receptor agonist. Can competitively antagonize the effects of the FP receptor agonist Fluprostenol (HY-108560). AL 8810 methyl ester has no significant potency against TP, DP, EP(2), EP(4) receptor subtypes in cell lines .
Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost. Latanoprost is a prostaglandinF2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP) .
Cloprostenol isopropyl ester, a prostaglandinF2α analogs, is the intermediate of (+)-Cloprostenol (HY-107381). Cloprostenol isopropyl ester is a FP receptor agonist with a Ki value of 28 nM .
Ebopiprant (OBE022) is an oral and selective prostaglandinF2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively.
Latanoprost-d4 is the deuterium labeled Latanoprost. Latanoprost (PHXA41) is a prostaglandinF2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).
Latanoprost (Standard) is the analytical standard of Latanoprost. This product is intended for research and analytical applications. Latanoprost (PHXA41) is a prostaglandinF2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).
Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandinF2α. Carboprost tromethamine can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery .
Cloprostol, a synthetic derivative of prostaglandinF2α, is used as an ossified in veterinary medicine and the research of reproductive disorders in cattle, pigs and horses. (+)-5-trans Cloprostenol is a secondary impurity produced during the synthesis of (+) -cloprostenol .
5,7-Dihydroxy-11-ketotetranorprostanoic acid is a urinary metabolite of prostaglandinF2α and precursor to tetranor-PGF metabolites, exhibits hardly activity in blood pressure assay and smooth muscle stiumulation assay .
15-Keto-PGA1 is a metabolite of PGA1 and has significant vasoconstrictive effects. PGA1 is also a vasoconstrictor and is more potent than equivalent doses of prostaglandinF2α (PGF2α) and angiotensin II .
15-Keto Bimatoprost-d5 is the deuterium labeled 15-Keto Bimatoprost. 15-Keto Bimatoprost is a prostaglandinF2α (PGF2α) analog that can be used for the research of ocular hypotensive[1][2].
Latanoprost (PHXA41) is a prostaglandinF2α analogue and can be used for glaucoma research. Latanoprost can effectively pass through cornea and be hydrolyzed by esterase to latanoprost acid. latanoprost acid is an F-prostaglandin (FP) receptor agonist, and can effectively reduce intraocular pressure (IOP) by increasing the outflow of aqueous humor through uvea .
Dinoprost-d9 is the deuterium labeled Dinoprost. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].
Dinoprost-d4 is the deuterium labeled Dinoprost. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].
PGF2α-isopropyl ester is a ProstaglandinF2α (HY-12956) derivative, which is active in lowering the intraocular pressure (IOP) through increased uveoscleral outflow of aqueous humor. PGF2α-isopropyl ester causes side effects of conjunctival hyperemia and ocular irritation .
Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .
AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandinF2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production .
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
Dinoprost tromethamine salt (ProstaglandinF2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour .
15-keto-ProstaglandinF2α (15-keto-PGF2α) is a metabolite of ProstaglandinF2α. ProstaglandinF2α. ProstaglandinF2α is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist and plays a key role in the onset and progression of labour .
AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandinF2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production .
FPRP/PTGFRN protein plays a key role in regulating prostaglandin F2-α (PGF2-α) signaling by inhibiting the binding of PGF2-α to its FP receptor. This inhibition reduces receptor number without changing the affinity constant, revealing subtle mechanisms. FPRP/PTGFRN Protein, Human (HEK293, His) is the recombinant human-derived FPRP/PTGFRN protein, expressed by HEK293 , with C-His labeled tag. The total length of FPRP/PTGFRN Protein, Human (HEK293, His) is 807 a.a., with molecular weight of 100-110 kDa.
The FPRP/PTGFRN Protein inhibits PGF2-alpha binding to its FP receptor, mainly by reducing receptor numbers. It interacts with CD9 and CD81, preventing myotube fusion in myoblasts during muscle regeneration. It also forms a complex with CD9, CD81, and IGSF8, potentially interacting with other tetraspanins like CD63, CD82, and CD151. These interactions highlight its regulatory role in prostaglandin signaling and muscle regeneration. FPRP/PTGFRN Protein, Mouse (HEK293, His) is the recombinant mouse-derived FPRP/PTGFRN protein, expressed by HEK293 , with C-His labeled tag. The total length of FPRP/PTGFRN Protein, Mouse (HEK293, His) is 811 a.a., with molecular weight of 110-120 kDa.
Dinoprost- 13C5 is 13C labeled Dinoprost (HY-12956). Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
8-iso ProstaglandinF2α-d9 is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
Latanoprost-d4 is the deuterium labeled Latanoprost. Latanoprost (PHXA41) is a prostaglandinF2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).
15-Keto Bimatoprost-d5 is the deuterium labeled 15-Keto Bimatoprost. 15-Keto Bimatoprost is a prostaglandinF2α (PGF2α) analog that can be used for the research of ocular hypotensive[1][2].
Dinoprost-d9 is the deuterium labeled Dinoprost. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].
Dinoprost-d4 is the deuterium labeled Dinoprost. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].
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